This is an observational study designed to investigate the effects of HAART treatment on the sleep patterns and related neurocognitive and psychosocial function of participants. Using questionnaires and actigraphy measurements, overnight sleep studies will assess sleeping patterns and daytime sleepiness. Peripheral blood levels will be measured over a 24-hour period at multiple time points. Neurocognitive and neuropsychological tests will be performed to explore sleeping habits, alterations in sleep-regulating cytokines and HIV-1 disease progression cytokines, and neurocognitive/neuropsychological performance.  Electroencephalography will be performed during wakefulness and sleep to determine if greater disease severity, sleepiness, sleep disruption, and neurocognitive impairment is associated with increased amounts of slow activity.

Ninety participants ages 3-17 are to be enrolled in this study in Clinical Centers at Baylor College of Medicine, Texas Children’s Hospital, MD Anderson Hospital, and University of Miami (Florida) School of Medicine.

C-TASC was asked to take over the data collection, management, and analysis responsibilities for this study in mid-stream.